Covid deaths in us from delta variant2/29/2024 For example, inaccessibility of intensive care service or emergency service due to overwhelming COVID-19 patients may result in excess deaths during the large community outbreaks. Overwhelming number of patients with Omicron infections can cause collateral damage of healthcare system. Our data showed that about two-thirds of the deaths among hospitalized patients with COVID-19 during the Omicron era were attributed directly to COVID-19, as were the majority of deaths among patients with COVID-19 during the Delta era. On the other hand, the government’s COVID-19 death figures are based on total deaths from any cause in patients recently diagnosed with COVID-19, so the overestimations are inevitable. One study revealed that COVID-19 was documented as the direct cause of death in more than 90% of hospitalized patients with COVID-19 who eventually died. Abbreviations: BMI, body mass index COVID-19, coronavirus disease 2019, IQR, interquartile range However, after adjustment of potential confounders, there was a trend toward being higher COVID-19-pneumonia-associated deaths in Delta variant infection than in Omicron variant infection (OR=3.84, 95% CI 0.95–18.65, p value=0.07) ( Supplemental Table 1).ĭata are presented as number (%) unless otherwise indicated. Unadjusted odds ratio (OR) for COVID-19-pneumonia-associated deaths in Delta group compared with those in Omicron group was 4.11 (95% CI 1.33–12.69, p value=0.01). Multivariable analysis exhibited that old age and underlying solid cancer were independently associated with COVID-19-pneumonia-associated deaths ( Supplemental Table 1). Univariable analysis revealed that old age, COVID-19 severity, variant types, and solid cancer were associated with COVID-19-pneumonia-associated deaths. The primary cause of death was COVID-19–associated pneumonia in both the Omicron (64%, 27/42) and Delta (88%, 37/42) eras ( P = 0.01). During the Omicron-dominant period, 42 (6%) of 654 patients with COVID-19 were admitted died ( Supplemental Figure 1). During the Delta-dominant period, 42 (11%) of 366 patient with COVID-19 were admitted died. The demographic and clinical characteristics, along with the causes of death of the COVID-19 patients, are shown in The study was approved by the institutional review board of Asan Medical Center (IRB No 2022-1431), and informed consent was waived because of the retrospective nature of this study.Ī total of 1020 COVID-19 patients were hospitalized at our center between July 2021 and March 2022, among whom 366 were admitted during the Delta-dominant period (Jul 2021- Dec 2021), and 654 were admitted during the Omicron-dominant period (Feb 2022- Mar 2022). The causes of death were classified into COVID-19 pneumonia, other causes, and indeterminate cause. We retrospectively reviewed the medical records of adult patients with COVID-19 who were admitted to Asan Medical Center, Seoul, South Korea, between July 2021 and March 2022. Therefore, we investigated the causes of death among COVID-19 patients with Delta- and Omicron-variant infections. However, these data were based on the mortality statistics record, so the exact causes of deaths were not known and uncertainty largely remains regarding the relative contribution of Omicron-variant infection to deaths. The recent study reported that substantial excess mortality occurred during the Omicron-dominant era, although Omicron variant may cause milder COVID-19.
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